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Welcome to the Srinivasan Lab! Established in 2023 at the University of Michigan, the Srinivasan Lab is dedicated to the discovery and development of novel therapeutics for neurodegenerative diseases, with an emphasis on hereditary cerebellar ataxias. Our group focuses on rectifying the dysfunctional circuitry that underlies these devastating diseases, using a wide range of scientific approaches from high throughput screening, genomics and transcriptomics, cell culture, and transgenic animal models.
Reframing Neurodegenerative Disease
Reframing Neurodegenerative Disease
Classically, neurodegeneration has been thought of as cell-based or proteinopathy diseases. While absolutely true, it is also abundantly clear that abnormal electrical activity is a major contributor to disease pathology and represents a desirable target for intervention. In fact, this is already being done through surgical means, using deep brain stimulation (DBS).
The Srinivasan Lab is focused on identifying specific channels that drive pathology in hereditary ataxias, and then discovering and developing small molecule modulators to rectify the improper firing.
The overall goal is to achieve "Pharmacological DBS".
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